My whole family has soap sensitivities, we use Ecosense Mela Power and set our washer to extra rinse

I like seventh generation or ECOS. Costco often has ECOS for bulk buying. I like the unscented stuff since regular detergent can be really strong for me. And in general these seem to be less harsh on clothing/bedding so they stay soft and last longer.

My skin is very sensitive and I use Tide for sensitive skin, and bounce free for fabric oftener. Maybe that will help you, too.

I would only use non-scented ones to start.

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I like Arm & Hammer Free & Clear Sensitive Skin. It's been really good for my partner who is allergic to almost everything.

For liquid detergent, Seventh Generation has been the only one I don't react to. For powdered non-enzymatic detergent, Molly's Suds has become my favorite recently. 

Tide free and clear has been consistently good for me. I deal with major allergies to scents and some ingredients but Tide has consistently been something I can use without issue.

Persil Free & Sensitive (Amazon only) or maybe Dirty Labs unscented.

The best detergent is not one that is soothing or innocuous to skin... but one that isn't there at all after a rinse. Of course, if it helps if it takes the dirt along with it down the drain, but that should go without saying... 🧐

We’ve been using Dr Bronner’s castelle soap instead of detergent, just put less than a teaspoon full in (it’s concentrated) and don’t add anything else. If something is extra gross I will put in unscented laundry sanitizer too

The best thing is to use white vinegar in place of fabric softener, then do an extra rinse.

I dry with wool balls and no dryer sheets.

All free & clear. NO fabric softener (liquid or sheets.) & lysol laundry sanitizer only. But make sure the detergent is LIQUID. I have uber sensitive skin & can’t use any other detergent or sanitizer. Also, I use dove sensitive skin (bar soap & body wash.) get detergent with the clear cap.)

Dirty Labs! It is super effective with enzymes. I use scented, but they have a free and clear regular and delicate.

Persil! They don’t have the itchy Ms: Methylisothiazolinone and its derivatives that make me itch like mad.

I have extremely sensitive skin and I narrowed a lot of irritation to soaps and synthetic conditioners. I tested this theory with hand soap, body wash and shampoo and it was a bingo. So I got a quarter cup of baking soda and ran an empty load with hot water to rinse my washing machine. Then I took all of my clothes out of my closet and drawers and re-washed everything with Molly's Suds. I have about 8 to 10 wool dryer balls for each load so I don't have to dry my clothes for so long thus reducing static. I've been doing this for about 7 years now. My clothes feel cleaner and softer. And I don't have any skin irritation.

Have you tested your water? A friend of mine struggled with this until they installed a water softener. Another tactic that worked was setting the washer to rinse 3x.

I use all free and clear, and wool balls in place of dryer sheets. Our clothes virtually have no scent besides smelling clean. I like what we use- it works and much more gentle on clothes.

I used to be really bad until switching to a sensitive detergent. I also set my washing machine to have an extra rinse cycle. It takes longer, but I don’t itch or sneeze anymore, so it’s worth it.

I have eczema and I use Nellie’s laundry soda. It’s unscented and has no unnecessary ingredients. It’s never caused any issues for my very sensitive skin, plus the tub lasts me a long time!

I don't have sensitive skin but love Dirty Labs. I believe they have an unscented version but the scented ones to me are very mild. It's very concentrated so you use only a tiny bit. You can buy online, I don't think they are in stores. 

*I also hate Zum! My friend uses it and I told her I can’t be in her house anymore. Of course she think it’s with “essential oils” so it’s fine. IT REEKS and it’s so strong! 🤮

Ozone machine + seventh generation is my laundry combination. (Ozone is because no laundry detergent out there can remove synthetic fragrance, but Ozone eventually can)

Definitely avoid synthetic fragrance ...that whole category has no safety regulations whatsoever and you'll never be able to tell the difference between allergen or real toxin.

I also wash my undershirts in reverse osmosis instead of tap water because that's just part of what I need to do to avoid acne and itching...the tap water in Florida is nasty. I wash my body and hair with distilled water, and my undershirts with reverse osmosis water (which is not quite as good as distilled water but can be made in larger amounts and the equipment can be easily hidden)

If you or someone you know has access to a Costco, I love their Kirkland brand detergent. I’ve tried their regular and their scent free, they’re both great.

Tide free and clear

Tide in the white bottle

I like the arm & hammer scent free

Nellie’s laundry soda is so good! And it cost almost nothing.

I use Kirkland free and clear. You can try it, but at some point this year another company will make it, so the formula may change.

Have you cleaned your washer? There may be fragrance residue left in it. I use Affresh, because that’s what my washer manual recommends, but others in this sub have liked other brands as well.

Whatever you choose, make sure you are choosing an extra rinse cycle, and only use a couple of tablespoons of detergent.

To get residues out of clean clothes, I would start with soaking batches of clothes overnight in the bathtub with a few cups of vinegar. Then ring out and throw in the washer for a rinse and spin cycle.

I'd double check that it isn't some other medical issue. If your skin itches when covered by fabric- it could be the fabric/detergent- but it could be something on your skin is irritated by the lack of air flow or the friction from clothing rubbing against you. If all else fails- see an allergy specialist. They can determine what you are allergic to and help narrow down your detergent search.

May I ask, what is it that has convinced you it is the detergent, if you have not so far found a detergent to switch to that makes the itch go away?

I ask this because itching can be a caused by many things, including some serious medical problems. I am a survivor of Hodgkins Lymphoma, and intense, all-over itch for no apparent reason was one of my symptoms that had been misdiagnosed and therefore delayed the beginning of correct treatment. if you have not already consulted your doctor, I urge you to do so.

This may seem crazy but I need to suggest it anyway- toilet paper is my big issue and it's the only thing you haven't mentioned. As prices keep going up manufacturing costs do too. Manufacturers will look for ways to cut costs and production methods are probably at the top of their "cut" list. The only brand I can tolerate is Scott but lately the sheets are thin like tissue paper so I use more. Another thing I do is carry a plastic bottle with water when I'm out and use it like a bidet rinse and then just dap myself dry with the toilet paper found in the rest room. (Just a suggestion since you seem to have run out of ideas.)

It’s usually the fragrance ingredients. If there’s been something you liked the performance of, try the unscented variant.

Tide Clean & Gentle Powder, The Unscented Co tablets and 365 by Whole Foods powder are fantastic choices. Powders also don’t have preservatives that can cause skin irritation. Even some “Free & Clear” liquids have the 2009 Contact Allergen of the Year in them.

Personally, I’d suggest a jug of 365 by Whole Foods Sport liquid and 1-2 T of their Oxygen Whitener powder. It’s probably the highest performing combo you can buy and the ingredients are super skin friendly.

I would also make sure, regardless of what products you use, to always use the maximum water level, deep rinse and extra rinses. That which isn’t left in the clothing can’t make you itch.

If the detergent is properly rinsed out, it shouldn't make you itch even if you are sensitive.

Unfortunately many machines are not great at rinsing, so your first step should be to add an extra rinse. Also make sure you are not using excessive detergent. If you have soft water, this means you need less detergent for a good wash, also that unfortunately that detergent is tougher to rinse out.

If this doesn't sort the problem, you could be sensitive to enzymes, as found in bio/enzyme detergents. Even Persil are not afraid to say that bio detergents "may cause irritation in babies or those with sensitive skin." The alternative, non-bio detergents, are not as good on stains or odours, but are effective if your clothes are not especially dirty or smelly.

It is very unlikely that fragrance is causing your problem, since the most common laundry fragrance ingredients (linalool, citronellol, geraniol) are not classed as sensitising, and are also the most common fragrancing in skincare, including baby products.

Tide Clean and Gentle powder is excellent (corrected from Free to Clean)

Consider Dirty Labs fragrance free.

Dadmode or Dirty Labs. But make sure there aren't suds left over in the drum when the load is done. If there are, that's your culprit for itchy skin. If not, it's the fragrance and the 2 I mentioned are not offensive in this category.